Friday, May 01, 2020

Human trials with the Coronavirus vaccine take risks for all of us

Human challenge studies and Alex Brauer from Sinclair Broadcast report on WJLA about human trials with volunteers who will be later deliberately inoculated with the Sars-Cov2 virus. 

Apparently volunteers will be given various vaccines in varied doses, and some will be challenged later with deliberate infection.  (It is not apparent that this would be done with total placebos.)

There are some risks.  One could be over-activation of the immune system (this is thought to happen with some vaccine attempts in the past like RSV).  Another could be Antibody dependent enhancement (ADE) which is known to happen with some viruses (like dengue). Peak Prosperity (Chris Martenson) has mentioned this risk on his videos as another “trick this virus could have up its sleeve”.  But ADE may be precluded with synthetic vaccines based on spike proteins, or with vaccines related to programming T-cells to recognize certain kinds of proteins.
Of course, this story raises the “moral” question related to risk-sharing. 
Update: May 13  

CNN today presented Abie Rohrig (known for debating activities related to Digital Natives and free speech and even a critique of Milo) as having volunteered to be infected with coronavirus after a vaccine trial.  Apparently he does not know if he had a vaccine or a placebo.  I don't know which vaccine this is.  Generally I feel that many of these vaccines have a good chance of at least blunting infection, and anecdotal reports continue to suggest that many young adults show few symptoms when infected, unless with a large innoculum.  It might be hard to tell if the vaccine prevented an infection that would not have taken hold anyway.  I thought I heard CNN say he had donated a kidney.  Being much older, I have always been sensitive about notions of body sanctity, but that's a topic for another time. 

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